it's too early to say, but husband asked for this supplement after going to Indonesia where he drank lots of graviola juice every day. he stayed there only for two weeks but in these two weeks he noticed a lot of extra energy and improved skin. he is taking this now but only 2 pills per day as he is taking other supplements too.
I also have this product in the full spectrum variety anyhow I love the price, benefits, quality, and improvement I have witnessed in my body. I have been telling all my friends & family about this wonderful supplement. I will continue to buy!
I originally bought it for my father to help him fight his brain tumor, as it is said that graviola can pass the blood-brain barrier. As I was curios about it, I took about 500-1000 mg myself. After an hour or so, my so called "internal-dialogue" has been silenced and it was strange for me as I'm a bit over-thinker with pretty "loud" thoughts. I found myself very calm and peaceful inside, but without any "highs" or cognitive impairments, I was very much able to perform my daily tasks. It also helped me with my panic attacks during stressful periods. So it definitely crosses the blood-brain barrier. Good stuff, but it should not be used continuously as it could reduce the amount of healthy bacteria in your digestive tract and could also lead to liver and kidney toxicity. Be moderate and stay healthy :)